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FLASH GENE

Symbol

NDN

contributors: mct/npt - updated : 19-12-2018

HGNC name	necdin, MAGE family member
HGNC id	7675

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

PWS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         during development likely contributes to the hypogonadotrophic hypogonadal phenotype in individuals with PWS (Miller 2009) constitutional   deletion     disturbs the migration of serotonin (5-HT) neuronal precursors, leading to altered global serotonergic neuroarchitecture and increased spontaneous firing of 5-HT neurons constitutional     --over   during osteoblast differentiation

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	cancer therapeutic target (Chapman 2009)

ANIMAL & CELL MODELS

	NDN knockout mouse model(Lee,05)with defects seen in PWS patients
	Necdin-deficient mice display early post-natal lethality with variable penetrance
	Necdin-deficient mouse is the only model that reproduces the respiratory phenotype of PWS (central apnea and blunted response to respiratory challenges)