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FLASH GENE
Symbol HOXB2 contributors: mct - updated : 24-08-2012
HGNC name homeobox B2
HGNC id 5113
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an homeobox DNA-binding domain
    • HOMOLOGY
    interspecies homolog to murine Hox-2.8
    homolog to Drosophila pb
    Homologene
    FAMILY
  • ANTP homeobox family
  • proboscipedia subfamily
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
  • regulator of tumor growth in breast cancer
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct target for regulation by PLZF in the developing CNS
    • cell & other
    REGULATION
    induced by retinoic acid which requires actin polymerization
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    ectopic expression of HOXB2 associated with a poor prognosis for all patients with pancreatic cancer
    tumoral     --over  
    in lung adenocarcinomas with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • prognostic indicator for stage I lung adenocarcinomas
    • Therapy target
    ANIMAL & CELL MODELS