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FLASH GENE

Symbol

HOXB2

contributors: mct - updated : 24-08-2012

HGNC name	homeobox B2
HGNC id	5113

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	one of several homeobox HOXB genes located in a cluster on chromosome 17
STRUCTURE	2.37 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see HOXB@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002145 2 - 1614 NP_002136 - 356 - 2003 12802276

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly Nervous nerve cranial nerve         nerve spinal nerve sciatic     Visual eye uvea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone subchondral     Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

an homeobox DNA-binding domain

HOMOLOGY

interspecies	homolog to murine Hox-2.8
	homolog to Drosophila pb

Homologene

FAMILY	ANTP homeobox family
	proboscipedia subfamily

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
	regulator of tumor growth in breast cancer

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

direct target for regulation by PLZF in the developing CNS

cell & other

REGULATION

induced by

retinoic acid which requires actin polymerization

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   ectopic expression of HOXB2 associated with a poor prognosis for all patients with pancreatic cancer tumoral     --over   in lung adenocarcinomas with poor prognosis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	prognostic indicator for stage I lung adenocarcinomas
Therapy target

ANIMAL & CELL MODELS