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FLASH GENE
Symbol HOXB4 contributors: - updated : 13-02-2004
HGNC name homeo box B4
HGNC id 5115
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 1.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map see HOXB@
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell null (stem cell)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text hematopoietic stem cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
helix-turn-helix,DNA binding domain
HOMOLOGY
interspecies homolog to murine Hox-2.6
homolog to Drosophila Dfd
Homologene
FAMILY ANTP family of homeobox proteins
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • part of a developmental regulatory system that provides cells with positional identities on the anterior posterior axis
  • mediating marked enhancement of hematopoietic stem cell regeneration
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS