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FLASH GENE
Symbol HOXB9 contributors: mct/npt/pgu - updated : 07-04-2010
HGNC name homeobox B9
HGNC id 5120
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 5.32 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   hormone
text structure
  • promoter contains several estrogen-response elements (ERE)
    • MAPPING cloned Y linked N status confirmed
    Map see HOXB@
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2711 - 250 - 2010 20080567
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text expression is detected in posterior regions of forelimb buds
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • helix-turn-helix, DNA binding domain
    • HOMOLOGY
    interspecies homolog to Drosophila abd-B
    homolog to murine Hox-2.5
    Homologene
    FAMILY
  • class I HOX gene family
  • Abd-B homeobox family.
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • promotes the formation of large, well-vascularized tumors that metastasize to the lung
  • induces cell fate alteration, cellular motility, angiogenesis, and lung metastasis
  • aberrant HOXB9 in breast cancer may enhance the oncogenic effects of activated ErbB2, EGFR (ErbB1), and other RTKs implicated in breast tumorigenesis
  • critical player in development of mammary gland and sternum and in regulation of renin which is closely linked with blood pressure control
  • E2-responsive gene and ESR1, ESR2 coordinate with MLL and MLL3 in E2-mediated transcriptional regulation of HOXB9
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by ESR1, ESR12 (Estrogen receptors ESR1 and ESR2 are essential for E2-mediated transcriptional activation of HOXB9) (
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    deregulated expression of HOXB9 contributes to breast cancer progression and lung metastasis by inducing several growth factors that alter tumor-specific cell fates and the tumor stromal microenvironment
    tumoral     --over  
    in 42p100 of breast cancers, specifically those of high histological grade
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS