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FLASH GENE

Symbol

LAMA5

contributors: mct/npt - updated : 28-01-2015

HGNC name	laminin, alpha 5
HGNC id	6485

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         null expression in prostate carcinoma constitutional     --other   aberrantly expressed in the pericystic ECM of AD polycystic kidneys constitutional       loss of function absence of functional LAMA5, leads to phenotype of Herlitz junctional epidermolysis bullosa (Schneider 2007)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mutation of the mouse laminin alpha5 gene results in a variety of developmental defects, including defects in kidney structure and function