| basic FUNCTION
| binding to cells via a high affinity receptor |
|
appears as a thin filament bridging the hemidesmosome with the anchoring fibrils (Rousselle 1997) |
|
mediating the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components |
|
important regulator of ADPKD cell proliferation and cystogenesis |
|
stimulates osteogenic gene expression in mesenchymal stem cells, in the absence of any other osteogenic stimulus (Klees 2007) |
|
activates extracellular matrix production and osteogenic gene focusing in human mesenchymal stem cells (Klees 2007) |
|
in intact skin, provides essential links to both the hemidesmosomal alpha6beta4 integrin and the collagen type VII molecules which form the anchoring fibrils inserting into the dermis (Schneider 2007) |
|
major contributions to the resistance of the epidermis against frictional stress but also for basement membrane regeneration and repair of damaged skin (Schneider 2007) |
|
predominant role in blood lymphocyte biology and identifies lymph nodes laminins and their integrin receptors in blood lymphocytes (Gorfu 2008) |
|
crucial motility-promoting factor for B-CLL lymphocytes and as a potential constituent favoring the dissemination of B-CLL lymphocytes through vascular basement membranes and possibly lymph node compartments (Spessotto 2007) |
|
extracellular matrix protein containing multiple domains implicated in various biological processes, such as embryogenesis and renal function  |
|
plays a crucial role in both epithelial and mesenchymal cell behavior by inhibiting WNT and activating PI3K signaling |
|
proper expression of LAMB3 and LAMA5 may regulate appropriate hair morphogenesis |
