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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CASP5

contributors: mct/npt/shn - updated : 05-04-2015

HGNC name	caspase 5, apoptosis-related cysteine peptidase
HGNC id	1506

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in glioblastoma multiforme constitutional     --over   can promote the angiogenesis significantly, possibly by inhibiting the ANGPT1/TEK pathway and promoting VEGFA pathway constitutional     --over   in lesional psoriatic skin

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mutated in lung cancer with highly metastatic potential in lung cancer