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FLASH GENE
Symbol CASP5 contributors: mct/npt/shn - updated : 05-04-2015
HGNC name caspase 5, apoptosis-related cysteine peptidase
HGNC id 1506
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal (Fas-associating protein with DEATH domain) FADD-like death effector domain
  • a conserved QACXG pentapeptide active site motif
  • an (A) 10 repeat within its coding region
    • mono polymer heteromer , tetramer
    isoforms Precursor precursor producing two subunits,large (20kDa) and small (10kDa) that dimerize
    HOMOLOGY
    interspecies ortholog to CASP5, pan troglodytes
    Homologene
    FAMILY
  • caspase family of cysteinyl-aspartate specific proteases
    • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,cytosolic
    text stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli
    basic FUNCTION
  • caspase 5, cysteine containing aspartate-specific protease, inducing apoptosis in fibroblast, lacking convertase activity
  • potentially involved in procytokine activation
  • may be a suppressor gene of highly metastatic potential in lung cancer
  • having pro-apoptotic and pro-inflammatory activities
  • changes of CASP2 and CASP5 activities could be indicative of their involvement in the cervical malignancy mechanisms
  • CASP5 and the inflammasome may have an important role in the inflammatory response in psoriasis
  • concerted endoproteolytic activity of CASP5 and CASP10
  • may work predominantly in concert with caspase-1 in modulating human retinal pigment epithelial inflammatory responses (
  • both CASP4 and CASP5 are functionally important for appropriate responses to intracellular Gram-negative bacteria
  • mainly participates in cell growth, apoptosis and other physiological process
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cleaves and activates MAX after FXS mediated dephosphorylation (
  • cleaves Periphilin (
  • NACHT, LRR and PYD containing protein 1, NALP1 (
  • CASP4 and caspase-5 mediate IL1A and IL1B release from human monocytes after lipopolysaccharide (LPS) stimulation
  • CASP4, CASP5, and SCAF11 directly bind endotoxin (LOS/LPS) and can be activated in the absence of any co-factors
  • IL17A promoted CASP5 function via facilitation of the NLRP1-inflammasome
    • cell & other
    REGULATION
    Other regulated by IFNG and lipopolysaccharide
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in glioblastoma multiforme
    constitutional     --over  
    can promote the angiogenesis significantly, possibly by inhibiting the ANGPT1/TEK pathway and promoting VEGFA pathway
    constitutional     --over  
    in lesional psoriatic skin
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mutated in lung cancer with highly metastatic potential in lung cancer