Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MDFI contributors: mct/npt - updated : 26-08-2019
HGNC name MyoD family inhibitor
HGNC id 6967
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal I-mfa domain
    • HOMOLOGY
    interspecies homolog to murine I-mfa
    Homologene
    FAMILY
  • myogenic factor D family (MYOD) inhibitor
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • repressor of myogenic helix-loop-helix class transcription factors
  • involved in the patterning of somites
  • functions as a molecular switch to suppress the store dependence of TRPC1
  • MDFI and MDFIC interact with SERTA domain proteins SERTAD1, SERTAD2, SERTAD3, SERTAD4) and negatively regulate their transcriptional activity
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physical and functional interaction with Zic proteins can play a role in the vertebrate development
  • physically interacts with TRPC1 (interaction is mediated by the C-terminal cytoplasmic tail of TRPC1 and the C-terminal cysteine-rich domain of MDFI)
  • interacting with TCF3 (inhibition of TCF3 binding)
  • specifically interact with SERTAD1 through its C-terminal I-mfa domain
  • also specifically interacts with other SERTA domain-containing proteins, including SERTAD3 and SERTAD4, through its I-mfa domain
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly methylated in Colorectal cancer tissues when compared with adjacent normal colorectal tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • with SSTR2, and CMTM3 having a potential role as biomarkers for colorectal cancer
  • association of higher methylation of the MDFI promoter with non-small cell lung carcinoma (NSCLC) may be specific to females, non-smokers and people aged &
    • 8804;65 years
    Therapy target
    ANIMAL & CELL MODELS