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FLASH GENE

Symbol

MDFI

contributors: mct/npt - updated : 26-08-2019

HGNC name	MyoD family inhibitor
HGNC id	6967

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001300806 5 - 1692 NP_001287735 25 246 - 2017 28782576 NM_001300804 6 - 1913 NP_001287733 - 246 - 2017 28782576 NM_005586 5 - 1606 NP_005577 25 246 - 2017 28782576 NM_001300805 4 - 1423 NP_001287734 - 185 - 2017 28782576

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system uterus     highly   female system placenta     highly Urinary bladder       highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	sclerotome

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

C-terminal I-mfa domain

HOMOLOGY

interspecies

homolog to murine I-mfa

Homologene

FAMILY

myogenic factor D family (MYOD) inhibitor

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	repressor of myogenic helix-loop-helix class transcription factors
	involved in the patterning of somites
	functions as a molecular switch to suppress the store dependence of TRPC1
	MDFI and MDFIC interact with SERTA domain proteins SERTAD1, SERTAD2, SERTAD3, SERTAD4) and negatively regulate their transcriptional activity

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	physical and functional interaction with Zic proteins can play a role in the vertebrate development
	physically interacts with TRPC1 (interaction is mediated by the C-terminal cytoplasmic tail of TRPC1 and the C-terminal cysteine-rich domain of MDFI)
	interacting with TCF3 (inhibition of TCF3 binding)
	specifically interact with SERTAD1 through its C-terminal I-mfa domain
	also specifically interacts with other SERTA domain-containing proteins, including SERTAD3 and SERTAD4, through its I-mfa domain

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   significantly methylated in Colorectal cancer tissues when compared with adjacent normal colorectal tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	with SSTR2, and CMTM3 having a potential role as biomarkers for colorectal cancer
	association of higher methylation of the MDFI promoter with non-small cell lung carcinoma (NSCLC) may be specific to females, non-smokers and people aged &
	8804;65 years
Therapy target

ANIMAL & CELL MODELS