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FLASH GENE

Symbol

TOR1A

contributors: npt/mct/pgu - updated : 19-04-2010

HGNC name	torsin family 1, member A (torsin A)
HGNC id	3098

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	ectopic overexpression of both human and C. elegans torsin proteins results in a dramatic reduction of polyglutamine-dependent protein aggregation suggesting a role for torsins in managing protein folding
	It also suggest that breakdown in a neuroprotective mechanism that is, in part, mediated by torsins may be responsible for the neuronal dysfunction associated with dystonia