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FLASH GENE

Symbol

HOXB7

contributors: mct/npt - updated : 26-08-2015

HGNC name	homeobox B7
HGNC id	5118

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   caused epithelial-mesenchymal transition in epithelial cells, accompanied by acquisition of aggressive properties of tumorigenicity, migration, and invasion tumoral     --over   associated with poor clinical outcomes, correlating significantly with a short survival time in patients who had lung adenocarcinoma

Susceptibility

To Neural tube defects (NTD)

Variant & Polymorphism other	HOXB7 hypomethylation is a risk factor for NTDs

Candidate gene
Marker	is a valuable marker of colorectal carcinoma prognosis
Therapy target
	System Type Disorder Pubmed cancer lung   could be a novel target for treatment of lung adenocarcinoma patients

ANIMAL & CELL MODELS