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FLASH GENE
Symbol HOXB7 contributors: mct/npt - updated : 26-08-2015
HGNC name homeobox B7
HGNC id 5118
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal octapeptide domain
  • helix-turn-helix, DNA binding domain
    • HOMOLOGY
    interspecies homolog to murine Hox-2.3
    homolog to Drosophila Antp,Ubx,abd-A
    Homologene
    FAMILY
  • Antp homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • regulation of a variety of proangiogenic stimuli (direct role in tumor progression)
  • part of a developmental regulatory system that provides cell with specific positional identities on the antero-posterial axis
  • having a a function in promoting tumor invasion through activation of Ras/Rho pathway by up-regulating FGF2, a known transcriptional target of HOXB7
  • involved in DNA double-strand break repair
  • regulates the expression of TALE HOX cofactors by increasing PBX2 and PREP1 and decreasing PBX1
  • plays an important role in the development and progression of human colorectal cancer
  • polyADP-ribosylation regulates transcriptional activities of HOX proteins such as HOXB7 and HOXA7
  • promote cell proliferation, angiogenesis, epithelial-mesenchymal transition
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interaction of HOXB7 with PARP1 that involves the homeodomain of HOXB7 and the first zinc finger domain of PARP1
  • HOXB7 promotes tumor progression in a cell-autonomous and non-cell-autonomous manner through activation of the TGFb2 signaling pathway
    • cell & other
    REGULATION
    Other transcriptionnaly regulated by Sp1/Sp3, NF-Y, YY1, and USF1 transcription factors
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    caused epithelial-mesenchymal transition in epithelial cells, accompanied by acquisition of aggressive properties of tumorigenicity, migration, and invasion
    tumoral     --over  
    associated with poor clinical outcomes, correlating significantly with a short survival time in patients who had lung adenocarcinoma
    Susceptibility To Neural tube defects (NTD)
    Variant & Polymorphism other HOXB7 hypomethylation is a risk factor for NTDs
    Candidate gene
    Marker
  • is a valuable marker of colorectal carcinoma prognosis
    • Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    could be a novel target for treatment of lung adenocarcinoma patients
    ANIMAL & CELL MODELS