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FLASH GENE
Symbol HOXB7 contributors: mct/npt - updated : 26-08-2015
HGNC name homeobox B7
HGNC id 5118
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 3.79 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence cytosine-phosphate-guanine/HTF
Binding site   silencer   transcription factor
text structure
  • two potential Sp1/ sp3 binding sites (-1228 and -46)
  • two canconical E-boxes, specific for USF-1 (-52 and -38)
  • an inverted CCAAT box located at nucleotide -69, that could bind NF-Y and YY1 factors
  • TATA-less promoter
    • MAPPING cloned Y linked N status confirmed
    Map see HOXB@
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1377 - 217 - 2007 17308091
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   highly
    Endocrinepancreas    
    Nervousbrain    
    Reproductivefemale systemuteruscervix highly
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    cell lineage
    cell lines in A375 melanoma cell line
    fluid/secretion
    at STAGE
    physiological period
    Text during early myelopoiesis
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal octapeptide domain
  • helix-turn-helix, DNA binding domain
    • HOMOLOGY
    interspecies homolog to murine Hox-2.3
    homolog to Drosophila Antp,Ubx,abd-A
    Homologene
    FAMILY
  • Antp homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • regulation of a variety of proangiogenic stimuli (direct role in tumor progression)
  • part of a developmental regulatory system that provides cell with specific positional identities on the antero-posterial axis
  • having a a function in promoting tumor invasion through activation of Ras/Rho pathway by up-regulating FGF2, a known transcriptional target of HOXB7
  • involved in DNA double-strand break repair
  • regulates the expression of TALE HOX cofactors by increasing PBX2 and PREP1 and decreasing PBX1
  • plays an important role in the development and progression of human colorectal cancer
  • polyADP-ribosylation regulates transcriptional activities of HOX proteins such as HOXB7 and HOXA7
  • promote cell proliferation, angiogenesis, epithelial-mesenchymal transition
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interaction of HOXB7 with PARP1 that involves the homeodomain of HOXB7 and the first zinc finger domain of PARP1
  • HOXB7 promotes tumor progression in a cell-autonomous and non-cell-autonomous manner through activation of the TGFb2 signaling pathway
    • cell & other
    REGULATION
    Other transcriptionnaly regulated by Sp1/Sp3, NF-Y, YY1, and USF1 transcription factors
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    caused epithelial-mesenchymal transition in epithelial cells, accompanied by acquisition of aggressive properties of tumorigenicity, migration, and invasion
    tumoral     --over  
    associated with poor clinical outcomes, correlating significantly with a short survival time in patients who had lung adenocarcinoma
    Susceptibility To Neural tube defects (NTD)
    Variant & Polymorphism other HOXB7 hypomethylation is a risk factor for NTDs
    Candidate gene
    Marker
  • is a valuable marker of colorectal carcinoma prognosis
    • Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    could be a novel target for treatment of lung adenocarcinoma patients
    ANIMAL & CELL MODELS