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FLASH GENE

Symbol

S100A8

contributors: mct - updated : 23-02-2015

HGNC name	S100 calcium binding protein A8 (calgranulin A)
HGNC id	10498

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in psoriasis and in epithelial skin tumors constitutional     --over   in numerous inflammatory diseases, such as sepsis, rheumatoid arthritis, inflammatory bowel disease, vasculitis and cancer constitutional     --low   in placentas of preeclampsia and HELLP syndrome (Buimer 2008) tumoral     --over   elevated levels of S100A8 or A9 in the ductal fluid, a near absence of pancreatic enzymes, and high levels of mucins were found to have significantly worse prognosis in pancreatic cancer constitutional     --over   overexpression of S100A8-S100A9 in neurons is an early step in oncogenic KRAS-induced gliosis

Susceptibility

to rheumatoid arthritis

Variant & Polymorphism

Candidate gene	for lipodystrophy and diabetes
Marker	S100A8 and S100A9 may serve as biomarkers for the detection of renal cell carcinoma
	potential marker of disease activity in patients with psoriatic arthritis
	dysregulated levels of S100A8 gene may be involved in sepsis pathophysiology and may be utilized as potential diagnostic biomarkers
Therapy target
	System Type Disorder Pubmed dermatology skin   inhibiting S100A8 and/or S100A9 may be a novel therapy targeting various molecular events involved in the initiation of psoriasis cancer urinary   attractive anticancer target for therapeutic intervention in kidney cancer

ANIMAL & CELL MODELS

S100a8 (-/-) condition is embryonic lethal