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FLASH GENE

Symbol

MEFV

contributors: mct/npt - updated : 11-07-2018

HGNC name	Mediterranean fever
HGNC id	6998

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MEFV

related resource

INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations Familial Mediterranean Fever at GeneDis

Susceptibility

to Behcet's disease to Fibromyalgia syndrome (FMS) to systemic onset juvenile idiopathic arthritis

Variant & Polymorphism other	increasing the risk of Behcet's disease
	heterozygous for rare missense variants of this gene may be predisposed to FMS, possibly triggered by environmental factors (Feng 2009)
	a significantly higher frequency of MEFV mutations systemic onset juvenile idiopathic arthritis (Ayaz 2009)

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology     the SIVA1-MEFV interaction may be a potential target for future therapeutic strategies

ANIMAL & CELL MODELS