Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CCL18 contributors: mct - updated : 23-11-2014
HGNC name chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
HGNC id 10616
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Scya3
intraspecies homolog to SCYA3
Homologene
FAMILY
  • intercrine beta family
    • CATEGORY signaling cytokine , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • lymphocytes (naive T cells, CD4+ and CD8+) chemoattractant
  • may play a role in both humoral and cell-mediated immunity responses
  • predominantly expressed in human atherosclerotic plaques and may participate in the atherosclerotic plaque formation
  • CCL18 and CXCL12 are homeostatic chemokines with high constitutive concentrations in serum
  • CCL18 plays a critical role in promoting breast cancer metastasis via its receptor, PITPNM3
  • differentiates dendritic cells in tolerogenic cells able to prime regulatory T cells in healthy subjects
  • inducing an M2 spectrum macrophage phenotype in the absence of IL4
  • may contribute to maintaining tolerance and/or suppressing deleterious inflammation by attracting memory Tregs into tissues, particularly in the lung, where it is highly and constitutively expressed
  • plays a crucial role in immune and inflammation responses
  • combined functions of CCL18 in mesenchymal and cancer cells might accelerate the progression of pancreatic ductal adenocarcinoma by promoting the epithelial-mesenchymal transition, invasion and migration of pancreatic cancer cells
    • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS immunity/defense
    text immune response
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • important modulator of CXCR4-dependent responses in pre-B ALL cells via interactions with GPR30 (PMIDS:
  • upon the binding of CCL18 to PITPNM3, PTK2B translocates from the cytoplasm to the plasma membrane to form a stable complex with PITPNM3, subsequently activating SRC kinase
  • induced the expression of the epithelial-mesenchymal transition (EMT) related gene SNAI1
  • CCL18 enhances hepatocellular carcinoma cell migration, invasion, and EMT through the expression of PITPNM3 and the activation of the NFKB1 signaling pathway
    • cell & other
    REGULATION
    activated by glucocorticoids in combination with IL-4
    induced by IL-4,IL-13 and IL-10 in macrophages
    phorbol myristate acetate (PMA) in several cell lines
    inhibited by IFN-gamma
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in childhood acute lymphocytic leukemia (ALL)
    constitutional     --over  
    in extrinsic atopic dermatitis patients
    Susceptibility
  • to HIV/acquired immunodeficiency syndrome (AIDS) (Omim: 609423)
    • Variant & Polymorphism SNP influencing HIV Type 1 transmission and AIDS disease progression
    Candidate gene
    Marker
  • is a potential biomarker for the diagnosis and prognosis of PDAC (pancreatic ductal adenocarcinoma)
    • Therapy target
    ANIMAL & CELL MODELS