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FLASH GENE

Symbol

CCL18

contributors: mct - updated : 23-11-2014

HGNC name	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
HGNC id	10616

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Endocrine pancreas         Reproductive female system uterus       Respiratory lung       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol   bone marrow       Homo sapiens Connective bone

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte Homo sapiens Lymphoid/Immune dendritic cell Homo sapiens Lymphoid/Immune macrophage Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	highly in placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Scya3

intraspecies

homolog to SCYA3

Homologene

FAMILY

intercrine beta family

CATEGORY

signaling cytokine , receptor membrane

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	lymphocytes (naive T cells, CD4+ and CD8+) chemoattractant
	may play a role in both humoral and cell-mediated immunity responses
	predominantly expressed in human atherosclerotic plaques and may participate in the atherosclerotic plaque formation
	CCL18 and CXCL12 are homeostatic chemokines with high constitutive concentrations in serum
	CCL18 plays a critical role in promoting breast cancer metastasis via its receptor, PITPNM3
	differentiates dendritic cells in tolerogenic cells able to prime regulatory T cells in healthy subjects
	inducing an M2 spectrum macrophage phenotype in the absence of IL4
	may contribute to maintaining tolerance and/or suppressing deleterious inflammation by attracting memory Tregs into tissues, particularly in the lung, where it is highly and constitutively expressed
	plays a crucial role in immune and inflammation responses
	combined functions of CCL18 in mesenchymal and cancer cells might accelerate the progression of pancreatic ductal adenocarcinoma by promoting the epithelial-mesenchymal transition, invasion and migration of pancreatic cancer cells

CELLULAR PROCESS

cell migration & motility

PHYSIOLOGICAL PROCESS

immunity/defense

text	immune response

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	important modulator of CXCR4-dependent responses in pre-B ALL cells via interactions with GPR30 (PMIDS:
	upon the binding of CCL18 to PITPNM3, PTK2B translocates from the cytoplasm to the plasma membrane to form a stable complex with PITPNM3, subsequently activating SRC kinase
	induced the expression of the epithelial-mesenchymal transition (EMT) related gene SNAI1
	CCL18 enhances hepatocellular carcinoma cell migration, invasion, and EMT through the expression of PITPNM3 and the activation of the NFKB1 signaling pathway

cell & other

REGULATION

activated by

glucocorticoids in combination with IL-4

induced by	IL-4,IL-13 and IL-10 in macrophages
		phorbol myristate acetate (PMA) in several cell lines

inhibited by

IFN-gamma

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in childhood acute lymphocytic leukemia (ALL) constitutional     --over   in extrinsic atopic dermatitis patients

Susceptibility

to HIV/acquired immunodeficiency syndrome (AIDS) (Omim: 609423)

Variant & Polymorphism SNP	influencing HIV Type 1 transmission and AIDS disease progression

Candidate gene
Marker	is a potential biomarker for the diagnosis and prognosis of PDAC (pancreatic ductal adenocarcinoma)
Therapy target

ANIMAL & CELL MODELS