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FLASH GENE

Symbol

HOXB6

contributors: - updated : 03-02-2007

HGNC name	homeo box B6
HGNC id	5117

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helix-turn-helix, DNA binding domain

HOMOLOGY

interspecies	homolog to murine Hox-2.2
	homolog to Drosophila Antp,Ubx,abd-A

Homologene

FAMILY

ANTP homeobox family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
	required for normal granulopoiesis and monocytopoiesis

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in acute myeloid leukemia

Susceptibility

to hypospadias

Variant & Polymorphism other	polymorphism increasing the risk of hypospadias

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS