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| Fancg(-/-) mice have normal viability and no gross developmental abnormalities but their primary splenic lymphocytes, bone marrow progenitor cells, and fibroblasts display spontaneous chromosome breakage and increased sensitivity to mitomycin C and ionizing radiation. Fancg(-/-) mice have decreased fertility and abnormal gonadal histology  | |
Fancg/Xrcc9 null mice show showed hypogonadism and impaired fertility and hypersensitivity to mitomycin C |
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fancg(-/-) mice presented with microcephalies and a decreased neuronal production in developing cortex and adult brain |