Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

FANCG

contributors: mct - updated : 13-02-2011

HGNC name	Fanconi anemia, complementation group G
HGNC id	3588

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

FANCG

related resource

Fanconi Anaemia Mutation Database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function in leukemia

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Fancg(-/-) mice have normal viability and no gross developmental abnormalities but their primary splenic lymphocytes, bone marrow progenitor cells, and fibroblasts display spontaneous chromosome breakage and increased sensitivity to mitomycin C and ionizing radiation. Fancg(-/-) mice have decreased fertility and abnormal gonadal histology
	Fancg/Xrcc9 null mice show showed hypogonadism and impaired fertility and hypersensitivity to mitomycin C
	fancg(-/-) mice presented with microcephalies and a decreased neuronal production in developing cortex and adult brain