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FLASH GENE
Symbol NRTN contributors: - updated : 29-10-2005
HGNC name neurturin
HGNC id 8007
Location 19p13.3      Physical location : 5.823.817 - 5.828.334
Synonym symbol(s) NTN
DNA
TYPE functioning gene
STRUCTURE 4.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Nervousnervecranial nerve   
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
intraspecies homolog to glial cell line derived neurotrophic factor
Homologene
FAMILY TGFB superfamily, GDNF subfamily
CATEGORY signaling growth factor
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • may regulate the development and maintenance of the central nervous system
  • involved in processes subserving both the organization of the cortical region during development and the functional activity and maintenance of the mature hippocampal neurons
  • may regulate the development and maintenance of the CNS
  • might control the size of non-neuronal cell population such as haemopoietic cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component homodimer, disulfide-linked
    INTERACTION
    DNA
    RNA
    small molecule
    protein RET ligand, through GFRA2 and/or GFRA1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in Hirschsprung disease
    Susceptibility contributor to susceptibility to Hirschsprung disease
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS