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FLASH GENE
Symbol P2RY6 contributors: mct - updated : 08-02-2013
HGNC name pyrimidinergic receptor P2Y, G-protein coupled, 6
HGNC id 8543
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments
  • one rhodopsin-like GPCR superfamily motif
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus P2ry6
    ortholog to murine P2ry6
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
  • rhodopsin-like receptor
  • extracellular nucleotides, via P2RY2 and P2RY6, regulate neutrophil migration by controlling TLR2-induced IL8 release from human monocytes
  • important contribution of P2RY6 signaling in enhancing vascular inflammation during systemic LPS challenge
  • mediator of UVB-radiation-induced inflammatory responses in keratinocytes
  • stimulates bone resorption by osteoclasts, and may play an important role in the regulation of bone cell function
  • may be involved in retinal information processing in different ways, probably by regulating the release of transmitters and/or modulating the radial flow of visual signals and lateral interaction mediated by horizontal and amacrine cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by selectively activated by UDP
    Other predominantly responding to UDP
    UDP induces chemokine expression in microglia and astrocytes of the injured brain by activation of P2RY6
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    when neurons are damaged, and could function as a sensor for phagocytosis by sensing diffusible UDP signals
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    therapeutic target during systemic inflammatory responses
    ANIMAL & CELL MODELS
  • P2Y(6)R(-/-) mice have increased bone mineral content, cortical bone volume, and cortical thickness in the long bones and spine, whereas trabecular bone parameters were unaffected
  • P2ry6-deficient mice and have shown that these mice have a defective response to UDP in macrophages, endothelial cells, and vascular smooth muscle cell