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FLASH GENE

Symbol

GNGT2

contributors: mct/npt - updated : 01-06-2016

HGNC name	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
HGNC id	4412

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

GGL domain

HOMOLOGY

interspecies

homolog to murine Gngt2

Homologene

FAMILY

G protein gamma family

CATEGORY

signaling , receptor membrane G

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,nucleus

basic FUNCTION

playing a crucial role in cone phototransduction

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

part of heterotrimeric G-protein, cone transducin, comprising GNAT2, GNB3 and GNGT2 subunits

INTERACTION

DNA

RNA

small molecule

protein

ARRB1 (functions of ARRB1 in binding to the beta1gamma2 subunits of heterotrimeric G-proteins and promoting G(betagamma)-mediated Akt signaling for NF-kappaB activation) (Yang 2009)

cell & other

REGULATION

activated by

TH (Liu 2007)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS