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FLASH GENE

Symbol

IDH3G

contributors: - updated : 02-05-2005

HGNC name	isocitrate dehydrogenase 3 (NAD+) gamma
HGNC id	5386

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	Xq28      Physical location : 153.051.221 - 153.059.967
Synonym symbol(s)	IDHG
EC.number	1.1.1.41

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head, opposite orientation
text	head to head with SSR4
STRUCTURE	8.00 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	cytosine-phosphate-guanine/HTF
text structure	CpG island shared with SSR4

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed - - - 1500 - 394 - Brenner exon 13,acceptor site - splicing - - 406 fetus, liver, spleen Brenner intron 12 - splicing - - - - Brenner 33 C terminal AA replaced by 20 differal residues exon 13 lacking intron 12 present - - - - - widely Brenner

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon       pancreas exocrine         Nervous brain         Reproductive female system breast mammary gland

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

secondary structure

heterooligomer of alpha, beta, gamma subunit

mono polymer

heteromer

HOMOLOGY

interspecies

homolog to murine Idh3g

Homologene

FAMILY

isocitrate and isopropylmalate dehydrogenase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix

basic FUNCTION	isocitrate dehydrogenase 3,gamma subunit,NADH dependent,catalyzing the third step of citric acid cycle
	catalyzing the oxidative decarboxylation of isocitrate into alpha-ketoglutarate

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS