| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --low
|
|
PKP1 loss secondary to promoter methylation, as well as other mechanisms, may promote the progression of Barrett esophagus (BE) to esophageal adenocarcinoma (EAC) in a subset of patients via decreased desmosome assembly and increased cell motility  | | constitutional
|
|
| --low
|
| |
results in an integral weakness within the desmosomal plaque, leading to desmosomal detachment and cell-cell separation | |
