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FLASH GENE

Symbol

INSIG1

contributors: mct - updated : 03-02-2017

HGNC name	insulin induced gene 1
HGNC id	6083

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   . cholesterol metabolic aberrations, induced through disruption of either DHCR7 or INSIG1 and INSIG2 , result in osteoblast differentiation abnormalities

Susceptibility

to coronary heart disease

Variant & Polymorphism SNP	rs9769826 of the INSIG1 gene was associated with coronary heart disease

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS