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FLASH GENE
Symbol IL12RB2 contributors: npt/ - updated : 03-02-2006
HGNC name interleukin 12 receptor, beta 2
HGNC id 5972
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an Ig-like domain
  • a cytokine receptor homologous domain
  • three FBN type III extracellular motifs
  • three tyrosine residues on the cytoplasmic tail (responsible for STAT4 activation)
    • mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
  • type I cytokine receptor family
  • type 2 subfamily
    • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 1 integral transmembrane protein
    basic FUNCTION
  • the response to Leprae determines IL12RB2 expression and functions in host defense in Leprosy
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS immunity/defense
    text positive control
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with IL12RB1
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS