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FLASH GENE

Symbol

IL12RB2

contributors: npt/ - updated : 03-02-2006

HGNC name	interleukin 12 receptor, beta 2
HGNC id	5972

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	89.54 kb     16 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed IL12RB2 16 - 4040 94.5 862 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune activated B lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an Ig-like domain
	a cytokine receptor homologous domain
	three FBN type III extracellular motifs
	three tyrosine residues on the cytoplasmic tail (responsible for STAT4 activation)

mono polymer

dimer

HOMOLOGY

Homologene

FAMILY	type I cytokine receptor family
	type 2 subfamily

CATEGORY

signaling cytokine , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
text	type 1 integral transmembrane protein

basic FUNCTION

the response to Leprae determines IL12RB2 expression and functions in host defense in Leprosy

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

immunity/defense

text	positive control

PATHWAY

metabolism

signaling

a component

heterodimerizing with IL12RB1

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS