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FLASH GENE
Symbol IL12RB2 contributors: npt/ - updated : 03-02-2006
HGNC name interleukin 12 receptor, beta 2
HGNC id 5972
Location 1p31.3      Physical location : 67.773.046 - 67.862.582
Synonym name IL-12 receptor beta 2
Synonym symbol(s) IL-12R-beta2, RP11-102M16.1
DNA
TYPE functioning gene
STRUCTURE 89.54 kb     16 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
KIAA1579 1p31.3 hypothetical protein FLJ10770 JAK1 1p31.3 Janus kinase 1 (a protein tyrosine kinase) LOC391045 1 similar to Solute carrier family 2, facilitated glucose transporter, member 3 (Glucose transporter type 3, brain) MRPS21P1 1p31.3 mitochondrial ribosomal protein S21 pseudogene AK3 1p31 adenylate kinase 3 DNAJC6 1pter-q31.3 DnaJ (Hsp40) homolog, subfamily C, member 6 LEPR 1p31 leptin receptor PDE4B 1p31 phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) DKFZp761D221 1p31.3 hypothetical protein DKFZp761D221 FLJ40873 1p31.3 hypothetical protein FLJ40873 INSL5 1p31.1-p22.3 insulin-like 5 FLJ23129 1p31.3 hypothetical protein FLJ23129 MI-ER1 1p31.3 mesoderm induction early response 1 SLC35D1 1p32-p31 solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 IL23R 1p31.3-p31.2 interleukin-23 receptor IL12RB2 1p31.3-p31.2 interleukin 12 receptor, beta 2 PAI-RBP1 1p31-p22 PAI-1 mRNA-binding protein LOC391046 1 similar to heterogeneous nuclear ribonucleoprotein C isoform b; nuclear ribonucleoprotein particle C1 protein; nuclear ribonucleoprotein particle C2 protein GADD45A 1p31.2-p31.1 growth arrest and DNA-damage-inducible, alpha GNG12 1p33-p31 guanine nucleotide binding protein (G protein), gamma 12 LOC391047 1 similar to NAD-dependent deacetylase sirtuin 5 (SIR2-like protein 5) ARHI 1p31 ras homolog gene family, member I FLJ23091 1p31.2 putative NFkB activating protein 373 LOC149224 1p31.2 similar to 40S ribosomal protein S7 (S8) RPE65 1p31 retinal pigment epithelium-specific protein 65kDa SDP35 1p31.2 cell cycle control protein SDP35 AF357533 1q31.3 thioredoxin 1 pseudogene 6 LOC388639 1 LOC388639 KIAA1365 1p31.2 densin-180 PIN1L 1p31 protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1-like
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 4040 94.5 862 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immuneactivated B lymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an Ig-like domain
  • a cytokine receptor homologous domain
  • three FBN type III extracellular motifs
  • three tyrosine residues on the cytoplasmic tail (responsible for STAT4 activation)
  • mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
  • type I cytokine receptor family
  • type 2 subfamily
  • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 1 integral transmembrane protein
    basic FUNCTION
  • the response to Leprae determines IL12RB2 expression and functions in host defense in Leprosy
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS immunity/defense
    text positive control
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with IL12RB1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS