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FLASH GENE

Symbol

HOXC11

contributors: - updated : 19-12-2005

HGNC name	homeo box C11
HGNC id	5123

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helix-turn-helix, DNA binding domain

HOMOLOGY

interspecies

homolog to murine Hox-3.7

Homologene

FAMILY

abd-b homeobox family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	involved in mouse posterior limb patterning
	may be playing a role in early intestinal development
	involved in developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binding to a promoter element of the lactase-phlorizin hydrolase

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       fused with NUP98 in acute myeloid leukemia with t(11;12)(p15;q13)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS