Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

SOX5

contributors: shn/pgu - updated : 20-03-2019

HGNC name	SRY (sex determining region Y)-box 5
HGNC id	11201

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

LAMSHF

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     coamplified with DADR and EKI1 in testicular seminoma tumoral     --over   in breast cancer tissues compared with adjacent healthy tissues, and overexpression of SOX5 was associated with a reduced overall survival rate in patients with breast cancer

Susceptibility

Variant & Polymorphism

Candidate gene	novel candidate gene for late-onset familial Alzheimer disease (LOAD with an important role in neuronal function
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast candidate therapeutic target in breast cancer progression cancer digestive liver may be a potential therapeutic target for HCC metastasis

ANIMAL & CELL MODELS

	Sox6 single null mice are born with mild skeletal abnormalities
	Sox5-Sox6 double null fetuses die with a severe, generalized chondrodysplasia
	silencing of the Drosophila ortholog of Sox5 leads to abnormal neuronal development and behavioral impairment