| basic FUNCTION
| involved in the regulation of embryonic development and in the determination of the cell fate |
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involved in the formation of the cephalic neural crest |
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a long form, expressed in chondrogenesis coactivator in association with SOX6 and SOX9 of the chondrocyte-specific enhancer of COL2A1 |
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modulator of LINE retroposons promoter activity |
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sex-determining region Y |
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transcription factor that has been shown to regulate chondrogenesis, oligodendrogenesis, and the sequential generation of cortical neurons |
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postmitotically controls the laminar positioning, molecular differentiation, and layer-specific pattern of subcortical axonal projections of subplate and deep-layer neurons |
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essential for endochondral skeleton formation  |
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regulates several stages of oligodendrocyte development in spinal cord |
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controls the sequential generation of distinct pallium-derived excitatory corticofugal projection neuron populations, regulating their subtype diversity |
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a role in roles in the generation of neuronal diversity during neocortical development |
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redundantly enhance chondrogenesis, but retard gliogenesis, and hinders melanogenesis, promotes neural crest generation, and controls the pace of neurogenesis |
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enhance transactivation by SOX9 in chondrocytes, but antagonize SOX9 and other SoxE proteins in oligodendrocytes and melanocytes, and also repress transcription through various mechanisms in several other lineages |
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controls the timing of cell cycle exit by neural progenitors at the G1-S transition by counteracting the mitotic effect of the WNT-CTNNB1 pathway |
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is an important brake on WNT-CTNNB1 mitogenic activity during the progression of neurogenesis |
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negatively regulates cell cycle progression and it is necessary and sufficient to promote cell cycle arrest at the G1-S transition |
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transcription factor involved in the regulation of nervous system development and chondrogenesis |
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controls dorsal progenitor and interneuron specification in the spinal cord |
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SOX9 and SOX5/SOX6 thus cooperate genome-wide, primarily through super-enhancers (SEs), to implement the growth plate chondrocyte differentiation program |
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transcription factors SOX5 and SOX6 exert direct and indirect influences on oligodendroglial migration in spinal cord and forebrain |
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islets in T2D display changes reminiscent of dedifferentiation and SOX5 is a regulator of beta-cell phenotype and function |
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SOX5 is a critical modulator of neurite outgrowth through the selective activation of DPYSL5 expression |
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SOX9 (SOXE group) is essential for chondrocyte fate maintenance and differentiation, and works in cooperation with SOX5 and SOX6 (SOXD group) and other types of transcription factors |
