| Symbol
| OGG1
| contributors: mct/pgu - updated : 07-11-2014
|
| HGNC name
| 8-oxoguanine DNA glycosylase
|
| HGNC id
| 8125
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
|
| gain of function
| |
in lung cancer with 3p del (affect prognosis) | | tumoral
|
| LOH
|
|
| |
in lung tumors | | constitutional
|
|
|
| loss of function
| |
in amyotophic lateral sclerosis ,impairing oxidative damage repair and leading to a loss of motor neurons | | tumoral
|
|
|
|
|
is associated with features of aggressive breast cancer  | |
| Susceptibility
|
lung cancer in Caucasian population smoking- and alcohol-related orolaryngeal cancer sporadic colorectal cancer to Alzheimer disease |
| Variant & Polymorphism
| Ser326Cys polymorphism plays an important role in risk for smoking- and alcohol-related orolaryngeal cancer |
|
R154H polymorphism associated with sporadic colorectal cancer |
| 
|
| Candidate gene
| OGG1 expressing patients have a worse relapse-free survival and overall survival and an increased risk of relapse at 5-years of follow-up |
|
prognostic marker that could be used to sub-stratify AML patients to predict those likely to fail conventional chemotherapies but those likely to benefit from novel therapeutic approaches that modulate DNA repair activity |
Marker
Therapy target
|
| | |
|
| Ogg1-/- mouse cells did not display spontaneous chromosomal abnormalities, e.g. chromosome breaks or fragments |