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FLASH GENE

Symbol

HOXC4

contributors: mct - updated : 20-01-2016

HGNC name	homeobox C4
HGNC id	5126

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Skin/Tegument skin

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	first trimester trophoblast, anterior limb

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an Antp-type hexapeptide motif
	an homeobox DNA-binding domain

HOMOLOGY

interspecies	homolog to rattus Hoxc4 (99.2 pc)
	homolog to murine Hoxc4 (99.6 pc)

Homologene

FAMILY	antp homeobox family
	deformed subfamily

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	involved in a developmental regulatory system providing cells with specific positional identities on the anterior-posterior axis
	playing a role in regulation of transcription
	controling lymphocyte activation and/or proliferation (Meazza 95)

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

text	anterior/posterior pattern formation
	cartilage development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding to ATTT elements (SREs) in the Igamma and I epsilon promoters (Schaffer 2003)

RNA

small molecule

protein

NFKB1 mediates TNFSF13-induced HOXC4 transcription

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS