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FLASH GENE
Symbol HOXC4 contributors: mct - updated : 20-01-2016
HGNC name homeobox C4
HGNC id 5126
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 splicing 2300 29.7 264 - Meazza (95)
  • encoding the same protein than variant 2
    • 2 splicing 1689 29.7 264 - Meazza (95)
  • differing in the 5' UTR compared to variant 1
  • encoding the same protein than variant 1
    		•
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Skin/Tegumentskin    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text first trimester trophoblast, anterior limb
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an Antp-type hexapeptide motif
  • an homeobox DNA-binding domain
    • HOMOLOGY
    interspecies homolog to rattus Hoxc4 (99.2 pc)
    homolog to murine Hoxc4 (99.6 pc)
    Homologene
    FAMILY
  • antp homeobox family
  • deformed subfamily
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in a developmental regulatory system providing cells with specific positional identities on the anterior-posterior axis
  • playing a role in regulation of transcription
  • controling lymphocyte activation and/or proliferation (Meazza 95)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • anterior/posterior pattern formation
  • cartilage development
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to ATTT elements (SREs) in the Igamma and I epsilon promoters (Schaffer 2003)
    RNA
    small molecule
    protein
  • NFKB1 mediates TNFSF13-induced HOXC4 transcription
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS