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FLASH GENE

Symbol

MTNR1B

contributors: mct - updated : 22-11-2012

HGNC name	melatonin receptor 1B
HGNC id	7464

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in Alzheimer disease

Susceptibility

to type 2 diabetes (T2D) to gestational diabetes mellitus (GDM) to autism spectrum disorders

Variant & Polymorphism other	SNP that augment expression and/or activity of islet melatonin receptors, increasing risk of type 2 diabetes
	mutations were found in upstream regulatory regions in autism spectrum disorders
	association of GDM with the rs10830963 (C/G) variant i

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete     blocking the melatonin ligand-receptor system could be a therapeutic avenue in T2D

ANIMAL & CELL MODELS