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FLASH GENE

Symbol

TFAP4

contributors: mct - updated : 24-04-2017

HGNC name	transcription factor AP-4 (activating enhancer binding protein 4)
HGNC id	11745

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	15.81 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003223 7 - 2147 NP_003214 - 338 - 2014 24500709

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine       Reproductive female system uterus cervix       female system ovary       Visual eye

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two leucine repeat elements and a helix-loop helix domain

HOMOLOGY

interspecies

homolog to murine Tfap4

Homologene

FAMILY

BHLH family of transcription factors

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,nucleus

basic FUNCTION	involved in signal-mediated trafficking of integral membrane proteins
	activating both viral and cellular genes by binding to the symmetrical dna sequence 5'- cagctg-3'
	is a new regulator of EMT that contributes to metastatic processes in CRC and presumably other carcinomas
	is an oncogenic antagonist of cellular senescence, that achieves this effect by direct repression of CDKN1A, CDKN2A, and may thereby critically contribute to MYC function and tumor progression
	maintains MYC-initiated cellular activation programs in CD8+ T cells to control microbial infection
	is a central mediator and coordinator of cell cycle progression in response to mitogenic signals and MYC activation

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

complexing with GMNN (repressor complex distinct from REST/NRSF to negatively regulate the expression of target genes in nonneuronal cells and may contribute to suppressing the precocious expression of target genes in fetal brain)

INTERACTION

DNA

RNA

small molecule

protein	transcriptional repressor of PHYHIP
	interacting with MYC
	CREB1, SP1, and TFAP4 play roles in modulating PPP2R2B expression
	modulates reversible and epigenetic silencing of the CD4 gene
	during the G2 phase of the cell division cycle, TFAP4 is targeted for proteasome-dependent degradation by the BTRC ubiquitin ligase
	BTRC-dependent degradation of TFAP4 is required for the fidelity of mitotic division
	TFAP4 is the transcription factor that was induced by MYC and sustained activation of antigen-specific CD8+ T cells
	direct transcriptional target of MYC

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in primary neuroblastoma patients is associated with poor clinical outcome tumoral     --over   in primary colorectal cancer (CRC) significantly correlated with liver metastasis and poor patient survival

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     inhibition of TFAP4 function may represent a therapeutic approach to block tumor cell proliferation

ANIMAL & CELL MODELS