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FLASH GENE
Symbol HOXC5 contributors: mct - updated : 24-02-2015
HGNC name homeo box C5
HGNC id 5127
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
helix-turn-helix,DNA binding domain
HOMOLOGY
interspecies homolog to murine Hox-3.4
homolog to Drosophila antp,Ubx,abd-A
Homologene
FAMILY
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     plasma membrane,junction
    intracellular
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • involved in mouse anterior limb patterning
  • HOXA5 and HOXC5, control diverse aspects of phrenic motor column (PMC) development including their clustering, intramuscular branching, and survival
  • is required for forelimb anterior patterning
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with promyelocytic leukemia zinc finger (ZBTB16) biochemically and genetically to restrict SHH expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    leads to anterior forelimb defects resulting from derepression of SHH expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS