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FLASH GENE

Symbol

HOXC5

contributors: mct - updated : 24-02-2015

HGNC name	homeo box C5
HGNC id	5127

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_153693 3 - 2081 NP_710160 - 153 - - NM_004503 2 - 1681 NP_004494 - 235 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

Text	first trimester trophoblast,anterior limb

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helix-turn-helix,DNA binding domain

HOMOLOGY

interspecies	homolog to murine Hox-3.4
	homolog to Drosophila antp,Ubx,abd-A

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	plasma membrane,junction
	intracellular
	intracellular,nucleus,nucleoplasm

basic FUNCTION	involved in mouse anterior limb patterning
	HOXA5 and HOXC5, control diverse aspects of phrenic motor column (PMC) development including their clustering, intramuscular branching, and survival
	is required for forelimb anterior patterning

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacts with promyelocytic leukemia zinc finger (ZBTB16) biochemically and genetically to restrict SHH expression

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     leads to anterior forelimb defects resulting from derepression of SHH expression

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS