Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

S100A6

contributors: mct/npt - updated : 24-12-2012

HGNC name	S100 calcium binding protein A6
HGNC id	10496

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in primary colorectal adenocarcinomas with liver metastases tumoral     --over   in osteosarcoma cells loss of its expression correlates with a metastatic phenotype constitutional     --over   overexpressed in neurodegenerative disorders and a proposed marker for Amyotrophic Lateral Sclerosis (ALS) constitutional       gain of function upregulation of astrocytic S100A6 in response to extracellular glutamate may be involved in neuronal damage under pathophysiological conditions

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	proposed marker for Amyotrophic Lateral Sclerosis (ALS)
Therapy target
	System Type Disorder Pubmed cancer digestive liver with SPP1, may be promising diagnostic markers and therapeutic targets for hepatocellular carcinoma

ANIMAL & CELL MODELS