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FLASH GENE
Symbol COX6A1 contributors: mct - updated : 07-10-2014
HGNC name cytochrome c oxidase subunit VIa polypeptide 1
HGNC id 2277
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , complex
isoforms Precursor
HOMOLOGY
interspecies homolog to rattus Cox6a1
ortholog to murine Cox6a1
Zebrafish Dr.7906
C.elegans F54D8.2
Homologene
FAMILY cytochrome C oxidase via family
CATEGORY enzyme , transport
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,membrane
basic FUNCTION
  • ferrocytochrome c:oxygen oxidoreductase
  • catalyzing the electron transfer from reduced cytochrome c to oxygen
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of the cytochrome oxidace c (ferrocytochrome c : oxygen oxidoreductase) complex,terminal enzyme in the mitochondrial respiratory chain ( oxidative phosphorylation OXPHOS)
  • heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes
  • COX6A1 exerts a protective effect against ROS-induced cell damage
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Cox6a1 null mice had thinned sciatic nerves and neurogenic muscular changes including small angular fiber and small group atrophy