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FLASH GENE

Symbol

COX6A1

contributors: mct - updated : 07-10-2014

HGNC name	cytochrome c oxidase subunit VIa polypeptide 1
HGNC id	2277

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Homo sapiens Nervous brain       moderately Mus musculus   nerve spinal nerve sciatic   highly Mus musculus Reproductive male system prostate     highly Respiratory lung       highly Mus musculus Urinary kidney       highly Mus musculus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , complex

isoforms

Precursor

HOMOLOGY

interspecies	homolog to rattus Cox6a1
	ortholog to murine Cox6a1
	Zebrafish Dr.7906
	C.elegans F54D8.2

Homologene

FAMILY

cytochrome C oxidase via family

CATEGORY

enzyme , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION	ferrocytochrome c:oxygen oxidoreductase
	catalyzing the electron transfer from reduced cytochrome c to oxygen

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport

PATHWAY

metabolism

energetic

signaling

a component	component of the cytochrome oxidace c (ferrocytochrome c : oxygen oxidoreductase) complex,terminal enzyme in the mitochondrial respiratory chain ( oxidative phosphorylation OXPHOS)
	heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes
	COX6A1 exerts a protective effect against ROS-induced cell damage

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

related resource

MITOP database

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Cox6a1 null mice had thinned sciatic nerves and neurogenic muscular changes including small angular fiber and small group atrophy