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FLASH GENE
Symbol COX6A1 contributors: mct - updated : 07-10-2014
HGNC name cytochrome c oxidase subunit VIa polypeptide 1
HGNC id 2277
DNA
TYPE functioning gene
STRUCTURE 2.55 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence cytosine-phosphate-guanine/HTF
Binding site   transcription factor
text structure
  • NR-2/GABP, YY1
    • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 593 - 109 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiens
    Nervousbrain   moderately Mus musculus
     nervespinal nervesciatic highly Mus musculus
    Reproductivemale systemprostate  highly
    Respiratorylung   highly Mus musculus
    Urinarykidney   highly Mus musculus
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , complex
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to rattus Cox6a1
    ortholog to murine Cox6a1
    Zebrafish Dr.7906
    C.elegans F54D8.2
    Homologene
    FAMILY cytochrome C oxidase via family
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • ferrocytochrome c:oxygen oxidoreductase
  • catalyzing the electron transfer from reduced cytochrome c to oxygen
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of the cytochrome oxidace c (ferrocytochrome c : oxygen oxidoreductase) complex,terminal enzyme in the mitochondrial respiratory chain ( oxidative phosphorylation OXPHOS)
  • heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes
  • COX6A1 exerts a protective effect against ROS-induced cell damage
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Cox6a1 null mice had thinned sciatic nerves and neurogenic muscular changes including small angular fiber and small group atrophy