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FLASH GENE
Symbol HOXC6 contributors: mct - updated : 16-01-2018
HGNC name homeo box C6
HGNC id 5128
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • homeobox DNA-binding domain, helix-turn-helix, postranscriptional regulation at protein level
    • HOMOLOGY
    interspecies homolog to murine Hox-3.3
    homolog to Drosophila Antp,Ubx,abd-A
    Homologene
    FAMILY
  • ANTP homeobox family
  • HOX family of transcription factors that bind to the TAAT sequences of target gene promoters to regulate gene expression
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
  • play an important role in morphogenesis and cellular differentiation during embryonic development
  • expression of HOXC6 induces expression of BCL2 and increase the cell viability
  • HOXC6 acts as a regulator in hematopoiesis and is involved in malignant transformation
  • has a role in all in prostate cancer stages, particularly in PCa cell proliferation
  • HOXC6 gene promotes the proliferation of gastric cancer cells while upregulation of MMP9 promotes migration and invasion of gastric cancer cells
  • HOXC6 may play a critical role in nasopharyngeal carcinoma (NPC) progression
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HOXC6 is an E2-responsive gene, and histone methylases KMT2D and KMT2C, in coordination with ESR1 and ESR2, transcriptionally regulate HOXC6 in an E2-dependent manner
  • is an important mechanism of the anti-apoptotic pathway via regulation of BCL2 expression
  • play an important role in several cellular events through the regulation of its functional biological targets such as BMP7, FGFR2, and PDGFRA
  • controls BCL2 expression, suggesting a potential role of HOXC6 in coordinating carcinogenesis in Head and neck squamous cell carcinoma (HNSCC) cell lines
  • HOXC6 directly binds to the specific TAAT, a sequence motif in the BCL2 gene promoter
  • expression of MMP9 was enhanced with an upregulation of HOXC6 expression while HOXC6 downregulation lowered MMP9 gene expression levels
    • cell & other
    REGULATION
    Other transcriptionally regulated by estrogen (E2)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in prostate cancer
    tumoral     --over  
    in human head and neck squamous cell carcinoma (HNSCC)
    tumoral     --over  
    in gastric cancer tissues and is associated with the depth of tumor invasion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may serve as a potential prognostic biomarker in nasopharyngeal carcinoma (NPC) patients
  • is a novel candidate biomarker for prostate cancer not only in early detection but also for monitoring of progression or response to therapy
    • Therapy target
    ANIMAL & CELL MODELS