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FLASH GENE
Symbol HOXC6 contributors: mct - updated : 16-01-2018
HGNC name homeo box C6
HGNC id 5128
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem, component of a cluster
STRUCTURE 13.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   hormone
text structure
  • promoter contains two putative estrogen response elements (EREs), termed as ERE1(1/2) and ERE2(1/2)
    • MAPPING cloned   linked   status confirmed
    Map see HOXC@
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1681 26 235 - 2015 26310814
    HOXC6 - V1
    - - 2081 - 153 - 2015 26310814
    HOXC6 - V2
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
     stomach   highly
    Endocrineplacenta    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    Text first trimester trophoblast, anterior limb
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • homeobox DNA-binding domain, helix-turn-helix, postranscriptional regulation at protein level
    • HOMOLOGY
    interspecies homolog to murine Hox-3.3
    homolog to Drosophila Antp,Ubx,abd-A
    Homologene
    FAMILY
  • ANTP homeobox family
  • HOX family of transcription factors that bind to the TAAT sequences of target gene promoters to regulate gene expression
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
  • play an important role in morphogenesis and cellular differentiation during embryonic development
  • expression of HOXC6 induces expression of BCL2 and increase the cell viability
  • HOXC6 acts as a regulator in hematopoiesis and is involved in malignant transformation
  • has a role in all in prostate cancer stages, particularly in PCa cell proliferation
  • HOXC6 gene promotes the proliferation of gastric cancer cells while upregulation of MMP9 promotes migration and invasion of gastric cancer cells
  • HOXC6 may play a critical role in nasopharyngeal carcinoma (NPC) progression
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HOXC6 is an E2-responsive gene, and histone methylases KMT2D and KMT2C, in coordination with ESR1 and ESR2, transcriptionally regulate HOXC6 in an E2-dependent manner
  • is an important mechanism of the anti-apoptotic pathway via regulation of BCL2 expression
  • play an important role in several cellular events through the regulation of its functional biological targets such as BMP7, FGFR2, and PDGFRA
  • controls BCL2 expression, suggesting a potential role of HOXC6 in coordinating carcinogenesis in Head and neck squamous cell carcinoma (HNSCC) cell lines
  • HOXC6 directly binds to the specific TAAT, a sequence motif in the BCL2 gene promoter
  • expression of MMP9 was enhanced with an upregulation of HOXC6 expression while HOXC6 downregulation lowered MMP9 gene expression levels
    • cell & other
    REGULATION
    Other transcriptionally regulated by estrogen (E2)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in prostate cancer
    tumoral     --over  
    in human head and neck squamous cell carcinoma (HNSCC)
    tumoral     --over  
    in gastric cancer tissues and is associated with the depth of tumor invasion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may serve as a potential prognostic biomarker in nasopharyngeal carcinoma (NPC) patients
  • is a novel candidate biomarker for prostate cancer not only in early detection but also for monitoring of progression or response to therapy
    • Therapy target
    ANIMAL & CELL MODELS