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FLASH GENE

Symbol

DNASE1L2

contributors: - updated : 19-07-2004

HGNC name	deoxyribonuclease I-like 2
HGNC id	2958

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed DNASE1L2-S - - 1257 32 278 peripheral blood leukocytes Shiokawa lacks the proline-rich domain DNASE1L2-L - splicing 1365 35 299 - Rodriguez

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	21AA signal peptide
	a proline-rich domain

HOMOLOGY

interspecies

homolog to murine Dnase1

intraspecies

homolog to dnase1

Homologene

FAMILY

DNAse 1 family of endonuclease

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION

basic FUNCTION

having a divalent cation-dependent acidic endonuclease activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

nucleic

signaling

nucleotide

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by

TNFA aand IL1Bvia the nuclear NFKB

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS