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FLASH GENE
Symbol DNASE1L2 contributors: - updated : 19-07-2004
HGNC name deoxyribonuclease I-like 2
HGNC id 2958
DNA
TYPE functioning gene
STRUCTURE 1.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence cytosine-phosphate-guanine/HTF
Binding site
text structure
  • DNA and calcium binding sites
  • two core sequences for GC boxes
    • MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1257 32 278 peripheral blood leukocytes Shiokawa
    lacks the proline-rich domain
    - splicing 1365 35 299 - Rodriguez
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 21AA signal peptide
  • a proline-rich domain
    • HOMOLOGY
    interspecies homolog to murine Dnase1
    intraspecies homolog to dnase1
    Homologene
    FAMILY DNAse 1 family of endonuclease
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION
    basic FUNCTION having a divalent cation-dependent acidic endonuclease activity
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    nucleotide
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by TNFA aand IL1Bvia the nuclear NFKB
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS