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FLASH GENE

Symbol

DNASE1L3

contributors: mct - updated : 25-02-2020

HGNC name	deoxyribonuclease I-like 3
HGNC id	2959

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SLEB3P

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in dermatomyositis/polymyositis and systemic lupus erythematosus constitutional germinal mutation       in hypocomplementemic urticarial vasculitis syndrome (HUVS) tumoral     --low   in late stage of clear cell renal cell carcinoma (ccRCC)

Susceptibility

to autoimmune disease to scleroderma

Variant & Polymorphism SNP	G82R and R206C in DNASE1L3 might be potential risk factors for autoimmune disease
	missense polymorphism rs35677470 in DNASE1L3, influencing scleroderma susceptibility

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

deletion of Dnase1l3 in mice resulted in aberrations in the fragmentation of plasma DNA